The main condition for increasing production of animal products is to strengthen the food supply and increasing the number of cattle due to the improvement of reproductive function. By reducing the reproductive function barrenness and infertility come, we can observe decreased offspring. However, despite the fact that the fight against many diseases is successful, there are still certain diseases that cause huge economic losses in farms, and in particular it is endometritis. When endometritis milk production is reduced, cows are prematurely culled, calves are liable to ill.
Predisposing factors for endometritis are weakening resistance of the organism as a result of incorrect, insufficient and inadequate feeding, ergasthenia, avitaminosis, trauma of the birth canal.
Inflammation of the uterus in animals observed in the postpartum period. Cause of the disease is microflora, penetrating into the uterus endogenously and exogenously under the condition of weakening of the overall resistance of the organism.
Taking into consideration the lack of preventive and curative effectiveness of existing antimicrobials, as well as the presence of side effects, the search for new medicines and treatments remains relevant.
Our task is to select the optimal treatment and prevention means of uterus inflammation.
Complex therapeutic measures in endometritis is aimed at timely removal of fluid from the uterus, the recovery of contractile function of the body and the suppression of the microflora in it, as well as to enhance the body's defenses.
Taking into consideration physical and chemical and pharmacological parameters of the most commonly used antibiotics for the development of treatment regimens, we chose the antibiotic chloramphenicol. Used in the formulations levotetrasulphin, tetrasolvin et al., aimed at prevention and treatment of inflammation of the uterus in cows. In these medicineschloramphenicol is contained in the complex with tetracycline antibiotic. As a solvent in these formulations propylene is used..
Using this formula avoids tetracycline antibiotics application which is included in analogues.
The experiment was conducted on two similar groups of cows. In the 1st group there used the drug containing chloramphenicol 5, sodium benzoate5, potassium sorbate and propylene glycol 5 to 100 g to treat uterus inflammation. The drug was injected 4 cows to treat postpartum purulent catarrhal endometritis. In the 2nd group tetrasolvin was used (the same number of animals). Drugs were injected in a dose of 50 ml utero every 48 hours in conjunction with symptomatic and pathogenic therapy means (content evacuation, vitamin, stimulation therapy et al.). In the 1st Group animals recovered in 3 injections, and in the second in 4.
Thus, the addition of antimicrobial chloramphenicol sodium benzoate and potassium sorbate, and propylene glycol as a solvent, increased anti-bacterial and fungicidal effect, which is proved by the experimental results.
- Sidorenko S. V. Resistance of microorganisms and antibiotic therapy // Rus. med. journal. V. 6. 1998. P. 717-725.
- Sakharov E. D., Egorova V. N. Modern view on the problem of immunotherapy // journal "Veterinary Practice '// 2002, № 1 (16), p. 31- 33.
- Alekhin E. K. How antibiotics work // Articles in Soros Educational Journal in text format Biology. 2000.