Biology

Chronic myeloid leukemia (CML) is the most frequently diagnosed case of the all chronic myeloproliferative diseases, which are affecting pluripotent stem cells of precursor myeloid, erythroid, B-lymphoid cells and megakaryocytes, also this is one of the common types of leukemia, occurring in 20 % of all cases of leukemia. Nearly a half of all patients usually discover the disease in the period of their higher professional and social activity, when they are between 30 to 50 years old [1, 2].

For investigation hard to studied species of birds it is requires to use new more accurate research methods. In a frame work of the project “Investigation ecology of Penduline tits” were used and evaluated innovative research methods and this article is concerned to them elucidated. All of following research methods were evaluated  on  two  species  of  Penduline  tits  in  Kazakhstan:  White-crowned  Penduline   Tit (WCPT)  Remiz coronatus and Black-headed Penduline Tit (BHPT) Remiz macronyx. On the basis of the research carried out we had have new data analysed of two Kazakhsatan’s species of Penduline Tits. As has been said that the researches were carried out in a frame of the project “Investigation ecology of Penduline tits” witch has received funding from the European Community’s Sixth Framework Programme.

The scientific works of 4th International Oligochaeta Taxonomy Meetings are presented. Modern methods of gathering and the account, taxonomy and the genetic analysis of different species of earthworms are resulted. Problems of systematisation of group are described. New methods of phylogenetic constructions are characterised. The basic of ecological researches in the biodiversity of oligochaetes analyzed in various regions of the world. The life forms informations is given in the aspects of modern ekologo-physiological researches. 

Literature review on natural-climatic conditions of urban areas is conducted in this article. Environmental assessment of urban areas is given. Natural and climatic environment of urban areas continues to lose its quality that makes it not only uncomfortable, but also dangerous to public health. Loss of quality of urban environment is associated not only with an extremely high level of physical-chemical air pollution, but also with noise, vibration and other anthropogenic impacts. These impacts on the surface layer of the atmosphere adversely affect the health of the population that uses urban areas both for recreation and for a walk or for other purposes. 

In article bioecological characteristics turgajsko-betpakdalinskoj populations Saiga tatarikа are reflected. The purpose of the conducted research consisted in participation of restoration of populations of saigas and their protection as the saiga is one of key kinds of a steppe ecosystem. For today the decision of this problem consists in that inhabitants of the Central Kazakhstan participated in all undertakings on protection of saigas because Betpakdalinsky population of saigas lives, migrates, is impregnated, prepared for winter time in this region. In article it is told about the spent actions in region of dwelling of this of populations.

Actuality. To date, assessment of the effects of the mutagen-induced production factors and the effects of environmental factors is carried out by detecting chromosomal damage by analysis of chromosomal aberrations and sister chromatid exchanges in peripheral blood lymphocytes. To evaluate the mutational event is necessary to use method of accounting for chromosomal aberrations, which is a highly sensitive methods of biological indication of human exposure to mutagens and production of environmental factors. In the molecules of DNA genetic information is encoded, mutagenic, acting on the cell, leading to breaks and rearrangements of chromosome structure [1]. In the formation of chromosomal aberrations important stage of the mitotic cell cycle, which occurred at the time of the impact of the mutagen.

The article presented the state of production and use of asbestos in Kazakhstan and the EECCA region. Discussion on potential health risks of asbestos production and use, including NGO recommendation for action. According the WECF \EcoForum partnership project «Civil Society and Sound Hazardous Waste Management in Kazakhstan» and High-Level Conference «Asbestos and POPs — policies and practices in Kazakhstan and the European Union» was identify next steps and recommendations to develop a strategy on asbestos in Kazakhstan and Kazakhstan’s position regarding Rotterdam Convention. 

Authors showed that interaction of diabetogenic chelators as Diphenylthiocarbazone and formed in Human some derivatives of 8-oxyquinolin with Zn2+-ions contained in B-cells result destruction of cells and develop- ing of 1 type diabetes. Preliminary elimination of Zn2+ — ion- from cells or blocking ions by not diabetogenic chelators protect B-cells of interaction with diabetogenic substances and as result — of developing of diabetes. 

Authors showed new experimental data on the state of histostructure of Liver and Exocrine Pancreas tissue in experimental diabetes approached on conditions of development to human 2 type diabetes caused by 4,8-dihydroxyquinolin-2-carboxylic acid — the substance actively synthesized in elderly human, unlike all known today more than 30 diabetogenic substances. It is established that, at the same time with destruction of pancreatic B-cells that is a direct cause of diabetes, a multiple destructive changes are developed in a Liver and in Exocrine tissue of Pancreas. Authors suppose these changes which are not belong to direct causes of developed diabetes, but can aggravate diabetes considerably.

A tissue culture experimental model is best for to study the direct effect of diabetogenic chemicals not possible products of its metabolisation on pancreatic B-cells. Authors are adopted to tissue culture model of isolated pancreatic islets histological and histochemical methods analysis of histostructure of islets and of insulin content in B-cells. The high quality results of analysis of histostructure of islets were obtained using Aldehydefuchsine method and most precise results of estimation of insulin content in B-cells by using of fluorescent Pseudoisocyanine and Immunofluorescent methods.

Authors showed that almost complete elimination of zinc-insulin complex from cytoplasm of B-cells caused   by 3 days prolonged administration of Glibenclamide to animals accompanied by complete disappearing of insulin and zinc-ions from B-cells. Next 6–7 days free of using of Glibenclamide result parallel complete recovery of amount of insulin and zinc in B-cells without any changes of histostructure of islets and function of B-cells.

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