BULLETIN OF THE KARAGAND A UNIVERSITY

Authors showed that intravenous injection amino acids Cystein and L-Hystidine prevent in majority of animals developing of experimental diabetes caused by chemicals formed in B-cells chelat complexes with Zn+2-ions. It was shown that in all cases administration of these amino acids prior injection of diabetogenic chelator as Diphe nylthiocarbazon (Dithizon) accompanied by almost complete absence of binding of Zn+2-ions in В-cells with formation of toxic complexes which result destruction and death of B-cells within short time. Authors suppose that protective effect is determined by presence in molecules of Cystein and L-Hystidine of SH-groups reacted with reacted with Zn+2-ions in B-cells with forming of not toxic complexes and not able to forming of complexes with a Dithizon. Authors showed also that from the used various histochemical and immunocytohistochemical methods insulin staining in B-cell more precise results was obtained using of immunohistochemical and fluorescent Diethylpseudoisocyanine methods. However, Aldehyde-fuchsine method and method Victoria 4R more suitable for investigation state of histostructure of pancreatic islets.
2015

The regular documentation of glucose measurements during insulin and / or oral drug therapy, meal intake, and special events in the daily life are crucial for doctors in the treatment of patients with diabetes mellitus. Therefore, we developed a method, which allows objective, rapid and comprehensive review of glucose profiles for the first time. On the basis of glucose values, either recorded by self-monitoring of blood glucose or by a continuous glucose monitoring with a sensor system, the Q-Score can easily be computed. Classification by Q-Score is simple, time-saving, and useful in terms of daily treatment routine. In addition, it involves analysis of the contribution of individual glycemic components expressed as the Q-Score and enables assessment of therapeutic efficacy. The method for determining the Q-Score, evaluation of glucose readings and self-control data as well as presentation of results and the therapeutic advancement will be implemented into the telemedicine information and communication system TeleDIAB®, which is available via world-wide.
2015

Type 2 diabetes mellitus is a complex metabolic disorder characterized by a relative deficiency of insulin in the presence of hepatic, adipose tissue, and skeletal muscle insulin resistance. The pathological process underlying the ß-cell dysfunction occurs already prior to the disease onset. While at the initial stage, ß-cell mass and insulin secretory function are sufficiently well maintained in the majority of individuals with type 2 diabetes, the later stages are characterized by aggravating insulin deficiency. The clinical course of the disease requires escalating therapy with oral drugs over time and eventually consistent application of insulin at the late stage for control of glycemia. Oral therapies are quite effective in improving the short-term insulin secretory capacity, but are incapable of preventing the inexorable decline in ß-cell function during diabetes progression. On the other hand, long-term use of antidiabetic agents is not without various side effects. Since a series of clinical trials have recently shown that implementation of short-term intensive insulin therapy in individuals with newly diagnosed type 2 diabetes can drastically improve and preserve ß-cell function and induce glycemic remission, this treatment strategy has gained considerable interest. However, whether early intensive treatment with insulin can really provide longer-term protection of the pancreatic ß-cells and may be preferable to other therapy modalities is a question that is not yet clearly established and requires appropriate clinical studies.
2015

In the article technogenic influence of Kirovskaya mine on a soil and plant cover of a sanitary protection zone of the enterprise is considered. During the analysis it was revealed that the selected tests of soils contain the significant amount of the heavy metals exceeding maximum permissible concentration. The analysis showed that great values reach such substances as chrome, copper, zirconium, zinc and nickel. Migration and accumulation by plants of substances of the 1–2 classes of danger in high values were set. Active migration from soil into plants is observed in such metals as boron, copper, chrome, zinc. Manifestation of toxic effect of heavy metals happens, as a rule, at a top level of anthropogenic pollution of soils by them and in many respects depends on properties and peculiarities of behavior of concrete metal.
2015

The article presents the results of the zoogeographic of Cerambycidae beetles family structure studies on the of the entomological collection of the University Nature Museum. Zoogeographical analysis involves the genesis of the fauna individual elements assessing and union types which are similar in time and place of their origin in faunal complexes (belonging to a particular type of fauna). When you select a geographic complexes you should take into consideration not only the general character of the area and zonal-landscape attachment of species, but also known data about the centers of the origin. This analysis has shown that the Holarctic genera makes up the core of the Kazakh uplands fauna at the generic level, and unique species of the indo-malayan genera makes the smallest part of the collection.
2015

The article presents the results of survey of two groups of male students (mean age 20 ± 2) from the Department of Physical Culture and Sports as well as the biology and geography departments. The heart rate variability was examined using a computerized complex «Varikard» (Russia). Estimation of heart rate variability was performed using mathematical statistics method of R.M.Baevsky. Cardiovascular system’s fitness was estimated by determining the type of response to the diving reflex using the method of cold-hypoxiahypercanic effect (CHE). There was a substantial stress and strain of regulatory systems at the majority of students of the Faculty of Physical Education and Sport, what shows a decline of adaptive reserves of the body, caused by excessive loads.
2015

The questions on the ecological projects with use of methodology of an estimation of risk and economic efficiency are surveyed at acceptance of the decisions about unhealthy industrial emissions. Thus it is  necessary to give attention to systems of long-term observations including: research of spatial — temporary distribution of chemical substance; optimization of a network of observation; optimization of parameters and agents of observation; automation of system of monitoring; organization of flows of the information reports. 
2015

The article analyzes the literary publications devoted to the research in recent years. The nature and level of accumulation of metals in various biological fluids of man reflects the degree of pollution in the natural anomalous geochemical provinces, and allows us to study human impacts. The situation which has developed in Kazakhstan, complex multifactorial causes environmental effects on public health, which creates the need to carry out actions aimed at the adoption of specific solutions to control the state of heavy metals in the environment in the «habitat — a man.» According to the literature, there is a relationship between the accumulation of metals in the environment and their accumulation in the human biological fluids.
2015

Studying of specific structure and condition of green plantings at the territory of industrial centers of the Karaganda region (Karaganda, Temirtau, Balkhash, Zhezkazgan) is carried out. The specific structure of wood flora on the surveyed points is presented by 13–18 main species. Vitality of wood plants made from 1 to 3 points. On a scale of the characteristic of environment by means of the fluctuating asymmetry, wood plants have got five marks on all research sites, which ecosystems were in areas with extraordinary anthropogenic pressure.
2015

The article discusses the issue of the protection of rare populations of Incarvillea semiretschenskia in Chu-Ili mountains, which are left unattended. The authors of this article studied the relic plants, which primarily due to human activities is now threatened with destruction. Incarvillea Juss. — the only genus of herbaceous plants in the family of Bignoniaceae. According to I.D.Illarionova 9 species of inkarvillea grow in Central Asia, one of species — I.Potaninii Maxim. It is endemic of southern Mongolia. Endemic of Kazakhstan Inc. semiretschenskia goes beyond the East Asian type of habitat and is found in the eastern part of the ancient, heavily destroyed Chu-Ili mountains. Saving the rare species of flora in Kazakhstan will help in achieving the main goal — deciphering the phylogeny and development of the concept of the final race. Now especially relevant issues of unique populations are inkarvillei semirechensk in Chu-Ili mountains and generic complex of Incarvillea in Asia.
2015

This article contains information about the impact of mobile communicationson the human body. And also it considers the harmful of mobile phones to the human health. It is clear that electromagnetic radiation from mobile phones has a negative impact on the physiological state and psyche of the person. Not following the rulesof using of mobile phones are doing a lot of damage to the health of people.
2016

Environmental pollution has an adverse effect on the functional state of the body of the child population. Exposure to environmental factors leads to the development of negative effects in the health status of the population, which translates into an increase in the incidence and deterioration of physical development. The unfavorable environment adversely affects the level of physical development and functional state in children, causing a high level of functional tension. The process of adaptation of schoolchildren living in different ecological zones of well-being, accompanied by a decrease in performance. Functional stress in children living in contaminated areas in line with the levels of pronounced stress and overexertion. The incidence of schoolchildren living in areas contaminated area reflected the reduced level of resistance of the body and testified about the negative impact neblagorpiyatnyh factors on the adaptive activity of the organism adolescents.
2016

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