Technology for producing extract from rose hips (rosa platyacantha)

This paper presents a method for obtaining dry extract from wild rose hips (Rosa platyacantha) using percolation. Ethyl alcohol at a concentration of 40% was used as an extractant. Three days settling at a temperature of 10 ± 5 °C to purify the extraction and filters with a pore diameter of 1.0 цт, 0.5 цт, 0.65 / 0.45 цт for threefold filtration were used. Drying of the extract was carried out using spray drying. The finished product meets the requirements of the State Pharmacopoeia of the Republic of Kazakhstan.

Relevance. Briar (Rosa) of the Rosaceae family (Rosaceae) is one of the most widely used medicinal plants in both official and traditional medicine, due to its rich chemical composition. Rose hips contain a large amount of vitamins and other biologically active substances: vitamin C, vitamin B1, vitamin B2, vitamin P, vitamin PP, carotene, tocopherols, flavonoids, lipids, organic acids, tannins, essential oils, carbohydrates, etc. [1, 2]. This genus includes 366 officially recognized species, 76 species of which grow on the territory of the Republic of Kazakhstan [3].

One of the many representatives of the genus dog rose, which is of scientific and practical interest, is the rose hip (Rosa platyacantha Schrenk). Scientists of the School of Pharmacy of the National Medical University are conducting research on obtaining pharmacopoeial herbal substances from various parts of the plant under study for the production of perfumes and cosmetics.

The aim of this work is to develop a technology for obtaining from the rose hips of a dry extract that meets the pharmacopoeial criteria.

Materials and methods. Description of the production process. In the production of the dry extract, the following ingredients are used: rose hips, harvested in accordance with the instructions for the preparation and storage of raw materials in accordance with the requirements of "Good practice of cultivation and collection of medicinal plants WHO" [4], purified water and ethyl alcohol 96% of pharmacopoeial quality.

The technological process consists of the following operations: preparation of raw materials, obtaining the extraction, cleaning, drying, packaging and labeling. The flow chart is shown in Figure 1.

Figure 1 Technological scheme of the production of dry extract from the rose hips

The calculated number of rose hips was crushed in a mill to a size of 0.5-3 mm, the crushed raw material was loaded into the maceration tank and filled with the calculated amount of extractant, ethyl alcohol 40%, soaked for 4 hours at a temperature not higher than 25°С. After the specified time, the swollen raw material was loaded into the percolator on a false bottom, filled with the extractant to the mirror and held for 24 hours at a temperature not higher than 25°С.

Then percolation was started at a speed of 1/24 rev/h (the ratio of raw material and extractant is 1:10). Then the drains were combined, the meal was pressed. The obtained semi-product was settled at a temperature of 10 ± 5T within 48 hours. The pooled extract was separated from the ballast mass, subjected to threestage filtration (pore size of filters 1.0 ^m; 0.5 ^m; 0.65 / 0.45 ^m), and dried using a spray dryer. The resulting powder was packaged in plastic bags, which were sealed; then they were labeled in accordance with the requirements of order No. 227 of 04/16/2015 [5] and packed in cardboard packs.

Results and discussion. Table 1 presents the technological parameters studied in the process of production of the dry extract from rose hips.

Table 1 -

of the

for the

of the dry extract from rose hips

On the basis of the developed plan for the production process critical stages were determined and optimal technological parameters were selected, samplings were compiled and tested. Regulatory documentation for assessing the quality of raw materials, semi-finished and finished products was predeveloped. The resulting finished product meets the requirements of the project IDA and the State Pharmacopoeia of the Republic of Kazakhstan [6-8].

Findings. The optimal technology has been developed and tested for obtaining dry extract from the wild rose hips. Regulated norms of technological parameters for critical technological stages have been determined. The quality of the finished product meets the requirements of the State Pharmacopoeia of the Republic of Kazakhstan. On the basis of the developed technology, laboratory regulations have been created for the production of dry extract from rose hips.

REFERENCES

1. Gretsky S.V. The method of exhaustive extraction from dog rose hips // Modern problems of science and education. 2015. №1-1. 1859 р.
2. Nevkrytaya T.A. Rosehip as a raw material for the processing industry // Urgent issues of improving the technology of production and processing of agricultural products. 2018. №20. P. 118-123.
3. Preliminary resource assessment of some species of wild rose in Central Kazakhstan // KazNU Bulletin. Biology series. 2013. №3/2 (59). P. 458-460.
4. Saitov A.S., Sakipova Z.B., Ibragimova L.N. The method of obtaining a phytosubstance from rosehips (Rosa Platyacantha) // Collection of materials of the IV International Scientific Conference "Scientific Discoveries". M.: 2019. P. 302-305
5. Order of the Minister of Health and Social Development of the Republic of Kazakhstan. 2015. №227 “On approval of the Rules for labeling medicines, medical devices and medical equipment”.
6. State Pharmacopoeia of the Republic of Kazakhstan. V.1. Almaty: Publishing house "Zhibek Zholy", 2008.
7. State Pharmacopoeia of the Republic of Kazakhstan. V.2. Almaty: Publishing house "Zhibek Zholy", 2009.
8. State Pharmacopoeia of the Republic of Kazakhstan. V.3. Almaty: Publishing House "Zhibek Zholy", 2014.