Prenosologic evaluation of status in adult population living in area falled «Proton» launch vehicle

It was evaluated functional status of women and men constantly living in area falled «Proton» launch vehicle.

It was identified physiological features with considering living place in township. Studies have shown an accelerated rate of aging in both men and women, as well as differences in the degree of stress of the central heart rate control loop. Taking into account places of residence differences were found between the parameters of PP, PRV, MVB, ADP and IN indices, and in men in ADP, MVB, MBV and AP, indicating that differences are greater in speed and volume characteristics of the system blood circulation, and the most unsatisfactory ratio was registered in men of the Karsakpai settlement. In Karsakpai women, the pulse pressure index (PP) was maximum against the background of low values of minute blood deflection (MBV) with a high value of peripheral vascular resistance (PVR) and low mean dynamic pressure (ADP), which is considered a sign of stagnant phenomena in the vascular bed. Women of Zhezkazgan and men in the village Karsakpai and Satpayev have a fast aging pace and they should pay attention to the lifestyle and if necessary it is recommended to undergo additional examination.

Introduction

Health condition as ecopathological problem is urgent last decade, whereas there is a tendency to increase and severity of diseases. Assesment of role of adverse effects linked with environment pollution on human body represents the main gap for medical sciences.

The environment is described by the presence of unfavorable anthropogenic factors that can influence on population health and likelihood of developing certain diseases. According to epidemiology of noninfective diseases the highest probability of formation of ecopathology is under the influence of chemical factors [1].

So far, little attention has been paid to the problem of the features of the influence of the environment on the state of health of certain population groups that have different sensitivity to the impact of adverse factors.

At present, changes in the environment have reached a qualitatively new level. The development of industry and transport, the increase in the production and consumption of energy, the intensification and chemicalization of agriculture, everyday life, urbanization and urban growth, the formation of territorial production complexes lead to environmental pollution, which already directly affects the health and morbidity of the population region [2].

In this regard fundamental hygienic research has acquired a new direction. It is definition of quantitative links between changes in the environmental factors and the characteristics of the disruption of population health status at the prepathological and pathological levels of the organism.

The main difficulties in this area are due to the variety of operating factors in environment and the differentiation of their individual influence on the population health: professional activity, living conditions, natural and climatic conditions, heredity.

The methodology for assessment risk of exposure of environmental factors on human health is a new, intensively developed worldwide scientific direction. The principles of this methodology stem from the concept of human hygiene and the environment.

Aim. The goal of this research was to assess population health status in prenosological stage in Zhezkazgan and Satpaev city.

Material and methods

Studies were conducted in 236 adults in Zhezkazgan, Satpaev and Karsakpai settlements in Karaganda region of Republic of Kazakhstan.

Selective method was used to form groups with the distribution of them into age cohorts. The groups included: men and women aged 20 to 60 years who did not have a disability and who were not on dispensary supervision (for the purpose of excluding somatic disability), residing in the territory for more than 10 years.

To assess the cardiovascular system (CVS) blood pressure (BP) was measured. This indicator indirectly reflects the volume of incoming blood to the aorta and therefore it is an important indicator of the functional state of the CVS.

For the subsequent calculations of hemodynamic parameters systolic (SBP) and diastolic (DBP) arterial pressure were recorded taking into account the time of ventricular systole.

Blood pressure measurement was carried out according to the Korotkov method with a Bio-PRESS TM manometer.

Age factor was taken into account in those participants who are over 50 years old. Because elasticity decrease of artery walls, depletion of the capillary system and atherosclerotic processes increase the pressure indices.

We calculated the parameters in terms of physiological parameters of systolic and diastolic pressure (SBP, DBP), heart rate (HR), age (A):

  • pulse pressure PP = APS - APD;
  • average dynamic pressure ADP = 0.42PP + APD;
  • systolic blood volume SBV= 100 + 0,5PP - 0,6APD - 0,6V (A — age of participant);
  • minute volume of blood MVB = SBV * HR;
  • peripheral resistance of vessels PRV = (SPD * 1333 * 60) / MVB;
  • index of circulatory insufficiency ICI = BPs / HR;
  • vegetative index of Kerdo VIK= (1 - APD / HR) * 100 %.

Variational pulsometry was carried by complex «Varikard», «Ramena» (RF, 2005). The measurement was carried out under conditions that corresponded to the requirements described in the guidelines for the study of the autonomic nervous system, as well as the recommendations of the European Association of Cardiology and the North American Association of Electrophysiology and Cardiorhythmology [3].

The electrodes were applied in 1 standard lead. The registration session was accompanied by the measurement of 256 values of 5 minutes RR intervals and calculation of the spectral power density of the cardiointervals.

Biological age (BV) was calculated according to V.P. Voitenko. The analyzed parameters were body weight (MT) in light clothing without shoes, systolic blood pressure (ABPsis), diastolic blood pressure (ABPdiast), pulse pressure (APp), delayed breathing after deep inspiration (DBinsp), delayed breathing after deep exhalation DBexhal), static balancing (SB), vital capacity of lungs (VCL), health self-assessment index (HSA).

Results and discussion

The ratio of the activity of peripheral hemodynamic parameters in women taking into account the places of residence is presented in Table 1.

Table 1

The ratio of the activity of peripheral hemodynamic parameters in women

Physiological indices

Valid N

Mean

Confidence -95.000 %

Confidence +95.000 %

Std. Dev.

Standard Error

1

2

3

4

5

6

7

Zhezkazgan

Age

75

45.42667

42.43392

48.41941

13.00745

1.501971

SBP

75

125.8667

120.5162

131.2171

23.25495

2.685251

DBP

75

79

75.97402

82.02598

13.15192

1.518653

PULSE

75

82.04

78.03907

86.04093

17.38937

2.007952

PP

75

43.13333

40.43361

45.83306

11.73391

1.354915

ADP

75

141.8493

135.2804

148.4183

28.55081

3.296763

SBV

75

45.95067

43.33644

48.56489

11.36228

1.312003

MVD

75

3805.32

3490.313

4120.327

1369.126

158.093

PRV

75

3505.724

3061.506

3949.943

1930.721

222.9405

VIK

75

0.02169

-0.08308

0.039701

0.266828

0.030811

Continuation of Table 1

1

2

3

4

5

6

7

Q

75

3.513088

3.30775

3.718427

0.892471

0.103054

II

75

126.3035

119.4912

133.1157

29.60835

3.418877

ICI

75

1.565436

1.468947

1.661926

0.419375

0.048425

AP

75

2.83836

2.691726

2.984994

0.63732

0.073591

Satpaev

Age

126

45.60317

43.112

48.09435

14.12916

1.258726

SBP

126

129.1667

124.9857

133.3476

23.71287

2.11251

DBP

126

82.7381

80.61468

84.86152

12.04337

1.072909

PULSE

126

41.54762

38.9266

44.16864

14.86559

1.324332

PP

126

143.2833

137.8779

148.6887

30.65782

2.731216

ADP

126

42.84048

40.85807

44.82288

11.24357

1.001657

SBV

126

3515.293

3300.371

3730.215

1218.972

108.5947

MVD

126

3765.448

3443.872

4087.024

1823.881

162.4842

PRV

126

-0.07355

-0.12351

-0.02359

0.283349

0.025243

VIK

126

3.467133

3.316927

3.61734

0.851925

0.075895

Q

126

121.2985

116.95

125.6471

24.66348

2.197197

II

126

1.606136

1.519952

1.692321

0.488812

0.043547

ICI

126

2.866222

2.751864

2.98058

0.648603

0.057782

Karsakpai

Age

5

45.8

26.33714

65.26286

15.67482

7.009993

SBP

5

138

127.6115

148.3885

8.3666

3.741657

DBP

5

82

65.81068

98.18932

13.0384

5.830952

PULSE

5

46

39.19913

52.80087

5.477226

2.44949

PP

5

151.32

125.0773

177.5627

21.13509

9.451899

ADP

5

43.92

27.42259

60.41741

13.28653

5.941919

SBV

5

3311.4

2417.5

4205.3

719.9214

321.9586

MVD

5

3889.806

2188.305

5591.308

1370.34

612.8347

PRV

5

-0.11523

-0.30583

0.07536

0.153498

0.068647

VIK

5

3.208333

2.744149

3.672518

0.373841

0.167187

Q

5

118.7

102.2638

135.1362

13.23725

5.919877

II

5

1.71416

1.501789

1.926531

0.171037

0.07649

ICI

5

2.9892

2.141276

3.837124

0.682893

0.305399

Differences were revealed between residences in different places in PP, SBV, PRV, MVB, ADP and IN indices. These indicators more characterize the velocity and volume characteristics of blood in peripheral vessels.

Related to blood pressure parameters to the values of the age norm (mean sample age is 45 years) it was revealed that indices were slightly higher and large range of differences was recorded mainly on the parameters of diastolic pressure.

The data indicate that in Karsakpai women, the pulse pressure index (PP) was maximum against the background of low values of minute blood deflection (MVD) with a high value of peripheral vascular resistance (PRV) and low mean of dynamic pressure (ADP), which is considered a sign of stagnation in vascular canal.

Biological age (BA) is an integrated expression of age pathology hidden or manifested in the form of not diagnosed diseases. Passport age (PA) although is a convenient measure which assesses the probability of functional capacity reducing in person and worsening his health state, however it is not an ideal measure due to the significant individual variability of aging of the organism.

Available data indicate that there are certain statistical relationships between rate of aging and a numerous social-hygienic factors that can be determined applying to a specific situation of human life.

Depending on the used methods to determine BA may reflect a decrease functional capacity of the body and its performance (functional age) or a decrease body's viability (gerontological age) [4, 5]. The available data in the literature indicate that biological age is an adequate indicator of a person's functional state. Today problem of assessing BA is closely related to the concept of physiological (normal) and pathological (premature) aging. This determines its importance during the solving a number of problems related topreventive ones, if take into account that the living conditions of a person can exert significant influence on BA.

The mean values of PA and BA were coincided only in women from Zhezkazgan, in women from Satpayev this difference was 1 year, and 4 years in women from Karsakpay.

Statistics on the rate of aging indicate that the degree of aging in Satpayev's women is consistent with statistical standards, for women in Zhezkazgan the degree of aging for 1 year is accelerated and they should pay attention to the lifestyle and, if necessary it is recommended to undergo a clinical and laboratory test, in women from Karsakpai the degree of aging was small.

In the SR index, it was revealed that according to the activity of regulatory systems, the women of the Karsakpay settlement (RSAI = 5) were more profitable in functional activity, although they were in the range of «sharply expressed functional tension».

This position is more favorable in relation to the others, because testifies to the active mobilization of protective mechanisms, including an increase an activity of sympatho-adrenal system and the pituitaryadrenal system [6, 7].

The most unsatisfactory position in the levels of functional tension was in women from Zhezkazgan, in whom the degree of centralization in the regulation of the structure of the SR contributed to a decrease in the activity of the autonomous circuit (in the form of a decrease in the spectrum of high-frequency waves (HF%) against the background of high values of the SDR index (624.9 ms. with a normal range of 40–80 ms).

Statistical indicators of the physiological status in men linked with places of residence are presented in Table 2.

Table 2 Indicators of physiological status in men taking linked with places of residence

Physiological indices

Valid N

Mean

Confidence –95.000 %

Confidence +95.000 %

Std. Dev.

Standard Error

1

2

3

4

5

6

7

Zhezkazgan

Age

10

50.6

40.52726

60.67274

14.08072

4.452715

Height

10

167.9

164.2144

171.5856

5.15213

1.629247

Weight

10

73.4

65.03579

81.76421

11.69235

3.697447

SBP

10

123

111.7902

134.2098

15.67021

4.955356

DBP

10

78

71.42632

84.57368

9.189366

2.905933

pulse

10

71.2

68.38263

74.01737

3.938415

1.245436

Din. de x

10

47.8

42.22001

53.37999

7.800285

2.466667

Din. sin

10

40.6

36.1237

45.0763

6.25744

1.978776

SAH

10

14.3

9.638883

18.96112

6.515793

2.060475

FBA

10

57.6944

51.82089

63.56791

8.2106

2.59642

DBA

10

50.3874

44.05165

56.72315

8.856773

2.800757

FBA-DBA

10

7.307

2.28134

12.33266

7.025389

2.221623

FBA-PA

10

7.0944

–0.48508

14.67388

10.59538

3.350553

PP

10

45

38.04798

51.95202

9.718253

3.073181

ADP

10

96.9

88.77182

105.0282

11.36241

3.593111

SBV

10

45.34

37.62385

53.05615

10.78643

3.410969

MBV

10

3215.14

2697.241

3733.039

723.9728

228.9403

PRV

10

2533.62

2054.745

3012.494

669.4208

211.6894

VIK

10

–0.09971

–0.20917

0.009757

0.153021

0.048389

Q

10

3.008212

2.866447

3.149978

0.198174

0.062668

II

10

112.2744

106.7152

117.8336

7.771227

2.457478

ICI

10

1.737481

1.533586

1.941375

0.285025

0.090133

AP

10

2.7171

2.402338

3.031862

0.440007

0.139143

Satpaev

Age

24

46.5

38.51915

54.48085

18.9002

3.857986

Height

24

168.375

165.6933

171.0567

6.35071

1.296333

Weight

24

75.625

69.73064

81.51936

13.95898

2.849366

SBP

24

127.9167

121.0989

134.7345

16.14585

3.295757

DBP

24

87.29167

83.02433

91.559

10.10587

2.062852

Pulse

24

84.08333

77.386

90.78067

15.86058

3.237527

Din. de x

24

43.95833

39.59755

48.31911

10.32717

2.108024

Continuation of Table 2

1

2

3

4

5

6

7

Din. sin

24

41.875

37.33679

46.41321

10.74735

2.193793

SAH

24

16.25

13.65819

18.84181

6.137908

1.252895

FBA

24

60.90088

57.76916

64.03259

7.416498

1.513886

DBA

24

47.8085

42.78854

52.82846

11.88822

2.426673

FBA-DBA

24

13.09238

9.308088

16.87666

8.961921

1.829344

FBA-PA

24

14.40088

8.028018

20.77373

15.09215

3.080673

PP

24

40.625

36.29753

44.95247

10.24828

2.091921

ADP

24

104.3542

99.30218

109.4062

11.96408

2.442157

SBV

24

40.0375

34.83565

45.23935

12.31898

2.514601

MBV

24

3370.929

2837.439

3904.42

1263.409

257.8922

PRV

24

2902.762

2302.16

3503.364

1422.342

290.3343

VIK

24

-0.07138

-0.16736

0.024595

0.227292

0.046396

Q

24

3.430651

3.187913

3.673388

0.574849

0.117341

II

24

123.4495

113.0495

133.8495

24.62917

5.027407

ICI

24

1.569104

1.423765

1.714442

0.344189

0.070257

AP

24

2.960333

2.707291

3.213376

0.599253

0.122322

Karsakpai

Age

5

36.4

21.77153

51.02847

11.78134

5.268776

Height

5

166.4

160.2166

172.5834

4.97996

2.227106

Weight

5

62.6

46.78157

78.41843

12.7397

5.697368

SBP

5

128

122.4471

133.5529

4.472136

2

DBP

5

82

76.44711

87.55289

4.472136

2

pulse

5

93.8

66.84702

120.753

21.70714

9.707729

Din.dex

5

48

36.89422

59.10578

8.944272

4

Din. sin

5

43.2

30.95843

55.44157

9.859006

4.409082

SAH ¯

5

12.8

7.430611

18.16939

4.32435

1.933908

FBA

5

58.5602

54.78877

62.33163

3.037396

1.358365

DBA

5

41.4556

32.25429

50.65691

7.410464

3.31406

FBA-DBA

5

17.1046

10.91637

23.29283

4.983817

2.228831

FBA-PA

5

22.1602

10.67619

33.64421

9.24889

4.13623

PP

5

46

39.19913

52.80087

5.477226

2.44949

ADP

5

101.32

96.89647

105.7435

3.562583

1.593236

SBV

5

51.96

40.47558

63.44442

9.249216

4.136375

MBV

5

4928.76

2777.579

7079.941

1732.498

774.7968

PRV

5

1800.172

1099.47

2500.874

564.325

252.3738

VIK

5

0.081587

-0.21995

0.383121

0.242847

0.108604

Q

5

3.871

2.792647

4.949353

0.868474

0.388393

II

5

147.5528

99.09412

196.0114

39.02719

17.45349

ICI

5

1.424837

1.018685

1.830988

0.327103

0.146285

AP

5

2.7852

2.300194

3.270206

0.390609

0.174686

 

There were differences in the settlements among the indicators of ADP, PRV, MBV, AP. Like women these indicators differed in volume and velocity characteristics and in the men of the Karsakpai settlement were the most unsatisfactory results (Fig. 2).

Calculation of the AP index showed that the men from Satpaev and Karsakpai settlement had satisfactory functional capacities of the circulatory system with moderate tension of the regulation mechanisms, and in the men from Zhezkazgan the functional capacities of the circulatory system were good.

In terms of cardiac rhythm, partly in quantitative characteristics of normal cardiac intervals RR, which we estimated by the RMSSD index, it was revealed that this was from the sample of the man from Zhezkazgan.

By frequency characteristics, iwas revealed that low frequency waves (VLF%) dominated in the spectrum in all settlements, and the differences were in the ratios of high-frequency (HF%) and vasomotor (LF%) waves (Fig. 2).

It was revealed that men froKarsakpai settlement are in a more unsatisfactory state, especially they entered the range of «pronounced tension of regulatory systems», which is typicafor the states of active mobilization of protective mechanisms.

Conclusions

  1. Taking into account places of residence differences were found between the parameters of PP, PRV, MVB, ADP and IN indices, and in men in ADP, MVB, MBV and AP, indicating that differences are greater in speed and volume characteristicof the system blood circulation, and the most unsatisfactory ratio was registered in men of the Karsakpai settlement. In Karsakpai women, the pulse pressure index (PP) was maximum against the background of lovalues of minute blood deflection (MBV) wita high value of peripheral vascular resistance (PVR) and low mean dynamic pressure (ADP), which is considered a sign of stagnant phenomena in the vascular bed.
  2. Women of Zhezkazgan and men in the village Karsakpai and Satpayev have a fast aging pace and they should pay attention to the lifestyle and if necessary it is recommended to undergo additional examination.
  3. In terms of SR in women it was revealed that the activity of regulatory systems in the more profitable functional activity was women of the Karsakpai settlement (RSAI = 5), although they were in the range of «sharply expressed functional tension», and the men of Karsakpai were in more unsatisfactory state and entered the range of «pronounced regulatory system voltage» which is characteristic of states of active mobilization of protective mechanisms. It was revealed that low frequency waves (VLF%dominated in the spectrum in all settlements, and the differences were in the ratios of high-frequency (HF%) and vasomotor (LF%) waves.
  4. The most unsatisfactory position was in levels of functional tension in women from Zhezkazgan, in whom the degree of centralization ithe regulation of the structure of the SR contributed to a decrease in the activity of the autonomous circuit (in the form of a decrease in the spectrum of high-frequency waves (HF%) against the background of high values of the SDR (624.9 ms with a normal range of 40–80 ms).
  5. Calculation of the AP indeshowed that in men from Satpaev and Karsakpai the functional capacities of the circulatory system function with moderate voltage of the regulatory mechanisms.

 

 

References

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Year: 2018
City: Karaganda
Category: Biology