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Development and research of gel-based toothpaste


The purpose of the workModern technology has allowed us to significantly expand the spectrum of toothpastes. They also can have therapeutic and prophylactic properties due to the inclusion in their composition of special active agents.Therefore, in this scientific work, we want to present L-arginine. L-arginine is one of the 20 basic amino acids that take an active part in protein formation. It has antibacterial, protective, regenerating and other properties. L-arginine stops to be produced when the body passes into the stage of adult life - after thirty years. Therefore, we propose to introduce it into the toothpaste. Development and study of the composition of therapeutic and prophylactic gel-based toothpaste with L-arginine.

Keywords: L-Arginine, toothpaste, gel basis, rotary evaporator, sodium alginate.

Toothpaste is specialized drug form which intended for hygiene, prevention and treatment oral disease. It should be considered when choosing toothpaste for fighting oral problems which its intended.

Currently, the production of toothpaste is a complex production process that takes a long period of research and modernization. Although, modern technology allowed us to expand the range of affect toothpaste.For instance, beside of its basic mission, it has therapeutic properties owing to including in composition special active additives. As such an additive in this scientific work we demand to show L-arginine.

L-arginine is a building material of proteins which consists of 20 basic aminoacids. L-arginine has antibacterial, protective,regenerating and other properties, which being conditionally indispensable substance for normal activity of human body. It is involved in the work of cardiovascular system, improving blood flow to internal organs, takes part in detoxication of liver, stimulates protective systems of our organism, promotes body cleansing of ammonia compounds.The human body synthesizes arginine independently, but due to malnutrition and some diseases, this process can slow down or stop at all.Besides, L-arginine ceases to be produced, when organism goes into adulthood-after 30. So, we offer include it in composition of toothpaste. When adding L- arginine in paste, it gains therapeutic affect yet. Due to the antibacterial and wound healing properties of arginine, this toothpaste can be used for gingivitis, stomatitis and other diseases of the oral cavity.

Sodium lauryl sulfate is an inexpensive detergent (surfactant) derived from coconut oil, is widely used in cosmetic cleaners, shampoos, bath and shower gels, toothpastes. In pastes, it is used to form a resistant foam and, as a result, more effective cleansing. Foam when brushing teeth occurs due to the fact that the composition of toothpaste includes foaming components, of which the most famous was sodium lauryl sulfate (SLS, SDS, sodium dodecyl sulfate). The foam formed by it cleans the plaque from the enamel.

Sodium alginate is the uniqueness of the biochemical composition of algae is a large number of biologically active substances: trace elements (especially iodine), vitamins, alginic acid and its salts (alginates). Thus, potassium, sodium and magnesium alginates are highly soluble in water. Soluble salts form viscous solutions. It is this property that determines their practical use as thickeners, stabilizers and binders in the production of food and drugs. When sodium alginate is added to the solution, a gel is easily formed. Sodium lauryl sulfate has an antimicrobial effect: the substance is able to increase the permeability of cell membranes, which ultimately leads to the death of bacteria. These properties make SLS another "protector" of our teeth from caries.

Glycerin – all known oily substance contained in toothpaste. Its task is to cover the enamel with a protective layer. It is necessary to ensure that the paste does not dry up. Without this component, the paste would become rigid, it would need to be constantly mixed, like paint.

Essential oil-mint is surprisingly effective tool for oral health, a great choice for people who follow oral hygiene. You can use peppermint oil to make homemade toothpaste, and you can add it to the solution for rinsing the mouth.

Methods. From the literature as the basis of our paste, we took a gel paste, where the main components are: detergent-sodium lauryl sulfate-this component depends on the foaming toothpaste; stabilizer-sodium alginate; binders-purified water and glycerin; essential oil-mint; biologically active substance-L-arginine.

The work was carried out in the laboratory of the Department of Drug Technology of the South Kazakhstan medical academy using the box of abacterial air environment BAVp-01- “Laminar-S.” - 1.2 (220.120.04).

We prepared the pasta that was sent for microbiological testing to the Branch of the RSE affiliate at the National Center of Expertise PHC KOOZ of the Ministry of Health of the Republic of Kazakhstan in Kentau. According to the analysis, the growth of microorganisms in our paste was in acceptable standards.

The preparation technology consists in the following: glycerin and purified water were added to the powder mixture, then a pre-prepared aqueous solution of sodium alginate was added, mixed until uniform. The calculated amount of condensed grape juice and sodium lauryl sulfate were added to the resulting mixture. In parallel with this, an aqueous solution of L-arginine was prepared, which was added to the resulting mixture. Last but not least, with constant stirring, we added a mixture of essential oils. The final stages of toothpaste technology are homogenization and standardization.

Results. According to ГОСТ 29188.2-91 «Пасты зубные. Общие технические условия», for the final result of the analysis, the arithmetic average of the results of two parallel determinations is taken, the allowable discrepancy between them should not exceed 0.1 pH units. The data analysis is shown below in Table 1.

Table 1.


In the test sample



5,5 – 10,5





Conclusion: Thus, according to the conducted literature studies, we proposed the composition and technology of therapeutic and prophylactic toothpaste with the addition of L-arginine and condensed grape juice. Work in this direction continues.


  1. Jan Bernard, Dan McGeehan, Toothpaste Before the Store Library Binding – January 1, 2012
  2. Saqib Ali, Robert Hill, David Gillam, Abrasivity of Bioactive Glass toothpaste for treating Dentine Hypersensitivity Paperback – October 1, 2012
  3. André O. Barel, Marc Paye, Howard I. Maibach Handbook of Cosmetic Science and Technology, Third Edition 3rd Edition.
  4. Tsai P., Weaver J., Cao G.et al. L-Arginine regulates neuronal nitric oxide synthesis production of superoxide and hydrogen peroxide//Biochem. Pharmacol. – 2005. – Vol.69. – P.971-979.
  • Year: 2019
  • City: Shymkent
  • Category: Medicine

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